Initial or salvage treatment with apatinib shows promise against radioiodine-refractory differentiated thyroid carcinoma

Initial or salvage treatment with apatinib shows promise against radioiodine-refractory differentiated thyroid carcinoma

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Objective: Sorafenib and lenvatinib have been recommended as standard tyro sine kinase inhibitors (TKIs) for progressive radioiodine-refractory differentiated thyroid carcinoma (RR-DTC).However, their efficacy remains limited with unresolved harry potter magsafe case drug resistance.Therefore, we conceived this open-label study based on real-world evidence to investigate the efficacy and safety of apatinib in patients wi th progressive RR-DTC.Methods: Off-label use of apatinib as either initial treatment or salvage treatment for sorafenib resistance was investigated.

The primary endpoint was progression-free survival (PFS) and the secondary endpoints included objective r esponse rate (ORR), overall survival (OS), and safety.Results: For all 28 enrolled patients, the median PFS was 15.1 months, w ith an ORR of 69.6%.

The median OS was not reached at the data cut-off.In det ail, the median PFS of 17.3 months and the ORR of 75% were determined in patients with TKI-naive RR-DTC (initial treatment group, n = 14).And, in patients with first-line sorafenib-resistant RR-DTC (salvage rawafricaonline.com treatment group, n = 14), a median PFS of 12.

0 months was reached, with an ORR of 45.5%.In the salvage treatment group, the media n OS from the start of apatinib administration was 20.6 months, reaching 89.

1 month s from sorafenib treatment initiation.Adverse events at grade 3 or higher occur red in 64.3% of all subjects treated with apatinib.Conclusions: This study demonstrated that apatinib shows promise against RR- DTC with tolerable toxicity, representing a novel initial treatment for progressive RR-DTC and effective salvage treatment for RR-DTC resistant to sorafenib.